Food allergy worsens asthma in a mouse model of atopic walking

Allergies are constantly on the increase in the most developed countries. What's more, there is a characteristic evolution of allergic diseases over the course of a person's life, from skin and food allergies to respiratory allergies such as asthma. The aim of this study was to understand the mechanisms involved in this evolution. Using a murine animal model, we showed that induction of wheat gluten food allergy aggravated the symptoms of mite asthma subsequently induced in mice. Moreover, this effect seems to be mediated by specific receptors (CCR9) enabling lymphocyte cells to migrate to the intestine. The aggravation of pulmonary inflammation thus appears to be dependent on CCR9 expression by T lymphocytes.

Partner: Work carried out as part of a thesis under the supervision of A. Magnan, G. Bouchaud and S. Brouard in partnership with UMR INSERM 1087 - CNRS UMR 6291 (Nantes).ravail réalisé dans le cadre d'une thèse sous la direction de A. Magnan, G. Bouchaud et de S. Brouard en partenariat avec l'UMR INSERM 1087 - CNRS UMR 6291 (Nantes).

Publication :
Castan L., Magnan A., & Bouchaud G. (2017). Chemokine receptors in allergic diseases. Allergy, 72(5), 682-690. http://doi.org/10.1111/all.13089

Castan L, Cheminant M-A, Colas L, Brouard S, Magnan A, Bouchaud G. (2018). Food allergen-sensitized CCR9+ lymphocytes enhance airways allergic inflammation in mice. Allergy. 73:1505–1514. https://doi.org/10.1111/all.13386